六合彩论坛

朱敏生博士
教授
电话:邮箱:zhums@lhcltforum.com 地址:研究方向:

平滑肌生理学、肠道致病菌病因学

  • 个人简介
  • 学术兼职
  • 代表性论文
  • 承担科研项目
  • 获奖情况

1995年毕业于中国科六合彩论坛 上海生物化学研究所,获理学博士学位。1999-2001年间在美国德州大学西南医学中心生理系从事博士后研究,2004年至今在六合彩论坛 任教授。主要研究方向为平滑肌生理学、肠道致病菌。曾首先在系统生物学水平较系统阐明平滑肌收缩行为的调控模式、发现顽固性便秘致病菌、溃疡性结肠炎的致病菌,并开发出噬菌体疗法。主持科技部973课题、国家自然科学基金重点项目、国家自然科学基金医学原创探索计划等。以通信作者发表数十篇科学论文,其中包括Science 2025)、JCI2022)、PNAS202520222015)、Nature Med 2013)、Gastroenterology(20082013)JACI2018)、Nature Communication2016)、Genome Biol(2016)等。获国家科技进步二等奖1项(排名2)。


中国细胞生物学会理事

江苏省发育生物学会监事


1. Jiang ZH, Wang Y, Gong JF, Chen X…….Wang FY*,   Zhang XN* and Zhu MS* An Aeromonas variant that produces aerolysin promotes   susceptibility to ulcerative colitis. Science 2025; 390(6775):850

2.Zhang   JH, Jiang ZH, Xuan J ……Zhang XN, Chen HQ, Zhu MS* and Chen X*. Long-chain   unsaturated free fatty acids control gut motility via nitrergic ganglia of   the enteric nervous system. PNAS 2025 Nov   11;122(45):e2513368122

3.Chen X, Qiu TT Wang Y Li N Zhang XN, Jiang   J, Zhu MSA Shigella species variant is causally linked   to intractable functional constipation. J Clin Invest.   2022;132(14):e150097

4.Zhou   YW, Sun J, Wang Y….Chen HQ, Wang P, Zhu MS* Tas2R Activation Relaxes   Airway Smooth Muscle by Release of Gαt Targeting on AChR Signalling. PNAS   2022Vol. 119 No. 26

5.Wang P, Zhao W, Sun J,   Tao T, Chen X, Chen HQ, Zhu MS*Inflammatory Mediators Mediate Airway Smooth Muscle Contraction   through a GPCR-TMEM16A-VDCC Axis and Contribute to Bronchial   Hyperresponsiveness in Asthma. J Allergy Clin Immunol   2018;141(4):1259-1268

6.Xu SCao S, Zou B, Yue Y, Gu C, Chen X, Wang P, Dong X,   Xiang Z, Li K, Zhu MS*,   Zhao QS*, Zhou GH* An alternative novel tool for DNA editing without   target sequence limitation: the structure-guided nucleaseGenome   Biology 2016;   17:186-195

7.Zhang   CH, Wang P, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Craige SM, Lifshitz LM, Jr KJF,   Fogarty KE, ZhuGe R, Zhu MS* The molecular basis underlying the   genesis of basal tone in internal anal sphincter. Nature Communication20167:11358

8.Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP,   Tao T, Sun J, Zheng YY, Du Jie, Li CJ, Gan ZJ, Gao X, Chen HQ and Zhu MS*.   Regulation of DLK1 by the maternally expressed miR-379-544 cluster may   underlie Callipyge polar overdominance inheritance. PNAS 2015;   112(44):13627-32

9. Chen, C.P., Chen, X.,   Qiao, Y.N., Wang, P., He, W. Q., Zhang, C.H., Zhao, W., Gao, Y.Q., Chen, C.,   Tao, T., Sun, J., Wang, Y., Gao, N., Kamm, K.E., Stull, J.T., and Zhu, M.S   * Roles in vivo for Myosin Phosphatase Targeting Subunit-1 T694 and T852   Phosphorylation sites in Bladder Smooth Muscle. J. Physiology 2015;593(3):681-700

10.He WQ, Qiao YN, Peng YJ, Zha JM, Zhang CH,   Chen C, Chen CP, Wang P, Yang X, Li CJ,, Kamm KE, Stull JT, Zhu MS*   Alteration of contractile phenotypes of intestinal smooth muscle from mice   deficient in myosin phosphatase target subunit 1. Gastroenterology 20131441450-1459

11. Zhang CH, Li Y, Zhao W,   Lifshitz LM, Li H, Harfe BD, Zhu MS*, ZhuGe R*. The TMEM16A   Ca2+-activated Cl- channel in airway smooth muscle contributes to airway   hyperresponsiveness. American Journal of Respiratory and   Critical Care Medicine.2013;187(4):374-813.

12. Zhang CH, Chen C,   Lifshitz L, Fogarty K, Zhu MS* and ZhuGe R*. Correspondence: Bitter   tastant-induced relaxation of airway smooth muscle does not involve BK   channels. Nature Medicine 2012; 18(5):648-650

13.He WQ Peng YJ, Zhang WC, Lv N, Tang   J, Chen C, Zhang CH, Gao S, Chen HQ, Zhi G, Feil R, Kamm KE, Stull JT, Gao X,   Zhu MS* Myosin light chain kinase is central to smooth muscle contraction   and required for gastrointestinal motility in mice. Gastroenterology   2008;135610-620


 

1.     国家自然科学基金重大研究计划(培育)课题, 非激活肌卫星细胞的体外扩增及其在肌肉衰老防治中的可能性应用(2018-1-2021.12

2.     国家自然科学基金面上项目苦物质及其受体T2R介导呼吸道平滑肌松弛的机制研究320711212021-01-01- 2024-12-31

3.     国家自然科学基金原创探索计划项目《顽固性功能性便秘致病菌Shigella sp PIB溯源和分子流行病学研究》82250003 (2023.1-2025.12)


2016年国家科学技术奖科技进步二等奖(排名2)